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A dual approach, a single goal

Make the most difficult tumors treatable

Who We Are

Altido Therapeutics is a clinical-stage biotechnology company advancing a novel T cell-based immunotherapy platform, CAR-TEAM, with a dual mechanism approach built to reach and engage difficult-to-treat solid tumors, like glioblastoma, that have long resisted conventional approaches. Our mission is to help improve the lives and outcomes of patients with glioblastoma and other drug-resistant cancers. We are backed by ARCH Venture Partners and Mass General Brigham Ventures and led by a team with deep experience building and leading cell and gene therapy companies.

Our Science

We built our CAR-TEAM platform to bring the full power of cellular immunotherapy to the most challenging cancers, starting with glioblastoma (GBM).

Our platform comes from Mass General Brigham and the lab of Marcela Maus, MD, PhD, a pioneering CAR-T researcher. It combines two established modalities — chimeric antigen receptor (CAR) T cells and bispecific T-cell–engaging antibody molecules (TEAMs) — into a single, autologous product that we call CAR-TEAM.

Each dose is designed to attack tumors from two angles at once: a patient’s own T cells are genetically modified to express a CAR targeting one tumor antigen and to simultaneously secrete TEAMs that direct both CAR-T and bystander T cells against a second antigen. This dual mechanism is purpose-built to address key barriers to targeting T cells to solid tumors, including tumor heterogeneity, antigen escape and T cell exhaustion.

Our lead program, ALTX-100, is in clinical development for glioblastoma.

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ALTX-100

Designed to overcome obstacles that have made cell therapies ineffective for primary brain cancers.

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in adults. It progresses quickly and is highly resistant to treatment, with fewer than 7% of patients surviving five years past their initial diagnosis. There are roughly 15,000 new diagnoses in the U.S. each year, and no therapy has ever been shown to meaningfully extend survival for patients after disease returns following initial treatment.

ALTX-100 offers a potential breakthrough in GBM treatment by giving the immune system two ways to recognize and address the tumor instead of one. Engineered CAR-T cells target EGFRvIII, a mutation found almost exclusively on cancer cells, while the TEAMs they secrete recruit both CAR-T and unmodified T cells to attack EGFR, a marker found on most GBM tumors. Additionally, ALTX-100 is delivered intraventricularly — directly into the cerebrospinal fluid in the brain. This bypasses the blood-brain barrier and concentrates the therapy where it is needed most.

Our Team

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Chip Clark

Chief Executive Officer

Chip Clark leads Altido Therapeutics as Chief Executive Officer, bringing more than three decades of leadership experience in the biopharmaceutical industry.

Prior to Altido, Chip served as Co-founder and Chief Executive Officer of Vibrant Biomedicines, a venture-backed company developing vaccines against bacterial pathogens. He also served as the President and Chief Executive Officer of Genocea Biosciences after co-founding Vanda Pharmaceuticals and acting as Chief Business Officer. Earlier, he served as a Principal at Care Capital, LLC, a biopharma venture capital firm. He started his career at SmithKline Beecham Corporation (now part of GlaxoSmithKline plc) in a variety of managerial roles. Chip currently serves on the boards of Aldeyra Therapeutics, MassBio, iBio, and Life Science Cares Boston.

Chip holds an MBA from The Wharton School at the University of Pennsylvania and a B.A. from Harvard University.

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Kate Lewis

Chief Operating Officer

Kate Lewis serves as Chief Operating Officer at Altido Therapeutics, where she leads operational strategy and execution.

Prior to Altido, she most recently served as Vice President of Portfolio Strategy & Operations at SalioGen Therapeutics, an early-stage transposon-based gene editing company. Kate previously acted as Vice President, Program Lead at Syndax Pharmaceuticals overseeing the Revuforj program, and Vice President, Global Program Executive at AAV gene therapy company Freeline, where she established program and portfolio management capabilities. Kate spent more than six years at bluebird bio in roles spanning Medical Affairs and Program Leadership, including leading the development of Zynteglo and Lyfgenia, . Before bluebird, Kate held roles in Medical Affairs, Strategic Communications and Program Management at Biogen and Genzyme.

Kate holds a B.A. in English Literature, magna cum laude, from Pomona College, and an M.A. in English Literature from the University of Iowa.

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Ray Stapleton, PhD

Chief Technology Officer

Ray Stapleton, Jr. serves as Chief Technology Officer at Altido Therapeutics, where he leads CMC, manufacturing, and technical operations strategy.

Prior to Altido, Ray was Chief Technology Officer at Vaxart, Inc., a clinical-stage biotechnology company developing oral recombinant vaccines, where he led CMC functions spanning drug substance and drug product development, manufacturing, MSAT, quality, and supply chain. He previously served as Chief Technology Officer and Executive Vice President at Genocea Biosciences, leading process and analytical development, manufacturing, and quality for the company’s personalized cancer immunotherapy programs. Prior roles also include President and Chief Operating Officer of ATCC, the global biological materials and standards organization; and as Senior Vice President of Technical Operations at Iovance Biotherapeutics and Synthetic Biologics. Earlier, Ray spent over 15 years at Merck, advancing from Manager, Quality Operations Microbiology to Executive Director, Global Vaccines Technology and Engineering, leading manufacturing validation, process engineering, and continuous improvement programs across vaccines, biologics, and sterile products.

Ray holds a Ph.D. in Microbial Ecology from the University of Tennessee, Knoxville, with postdoctoral training in biogeochemistry and extremophile microbiology at Oak Ridge National Laboratory, and a B.S. in Biology from the University of Mary Washington.

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Mike Lebel

Vice President, Project Leadership & Business Operations

Mike Lebel serves as Vice President, Project Leadership & Business Operations at Altido Therapeutics, where he drives cross-functional program execution and operational strategy.

Prior to Alitdo, he served in VP-level strategy and operations roles at Vibrant Biomedicines and Manta Medicines. Earlier, Mike was Vice President of Business Development at Casma Therapeutics and Vice President, Strategic Alliance Management at Ipsen. He spent more than six years at Celgene, advancing from Associate Director to Executive Director, BD & Global Alliances, where he led business development and global alliance activities. His earlier career included project management and alliance roles at Avila Therapeutics, Momenta Pharmaceuticals, and Shire Pharmaceuticals.

Mike holds an MBA from Suffolk University’s Sawyer Business School and a B.S. in Biochemistry from the University of Maine.

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Nick Keener, PhD

Vice President, CMC Strategy and Development

Nick Keener serves as Vice President, CMC Strategy and Development at Altido Therapeutics, where he leads strategic planning across chemistry, manufacturing, and controls for the Company’s therapeutic pipeline.

Prior to Altido, Nick acted as Vice President of Process, Data and Manufacturing Sciences at bluebird bio where he oversaw CMC lifecycle strategy across lentiviral vector and autologous cell therapy products, contributing to the EU approval of Zynteglo® and the March 2021 U.S. approval of Abecma® - the first CAR-T therapy approved for multiple myeloma. Nick began his biopharmaceutical career at Amgen as a post-doctoral fellow, where over his fifteen-year tenure he held roles of increasing responsibilities from principal scientist to director of process development and led the Manufacturing Sciences and Technology (MSAT) organizations at the company’s largest manufacturing site, supporting multiple blockbuster products.

Nick holds a Ph.D. and M.S. in Chemical Engineering from the University of Virginia and a B.S. in Chemical Engineering from North Carolina State University.

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Riccardo Biavasco, PhD

Associate Director of Analytical Development

Riccardo Biavasco serves as Associate Director of Analytical Development at Altido Therapeutics, where he leads the development of analytical methods.

Prior to Altido, Riccardo served as Associate Director at Vor Bio and as Senior Scientist at Beam Therapeutics. He began his industry career at bluebird bio, working in the company’s Analytical Development group, where he applied his expertise in gene therapy and hematopoietic stem cell biology – coordinating the development of characterization assays for hematopoietic stem cell drug products, including transduction efficiency, drug product phenotyping, and functional characterization of cell health, proliferation, and differentiation potential.

Riccardo holds a Ph.D. in Cellular and Molecular Biology, completed at the Telethon Institute for Gene Therapy, where his research focused on the development of a humanized mouse model for myeloid inflammatory neoplasms and the role of aberrant cellular senescence in hematopoietic stem and progenitor cells. He earned both his M.Sc. in Cellular and Molecular Biotechnologies and his B.Sc. in Medical and Pharmaceutical Biotechnologies from San Raffaele University, with thesis work on Erdheim-Chester disease and the development of gene therapy for β-thalassemia, respectively.

Scientific Founders

Marcela Maus, MD, PhD
Scientific Founder
Director, Massachusetts General Hospital Cellular Immunotherapy Program
Bryan Choi, MD, PhD
Scientific Co-Founder
Brain Tumor Surgeon, Massachusetts General Hospital Brain Tumor Center

Board of Directors

Nick Leschly
Chair and Co-Founder
CEO, Atida Bio; former CEO, bluebird bio and 2seventy bio
Chip Clark
Director
CEO, Altido Therapeutics
Steve Gillis, PhD
Director
Managing Director, ARCH Ventures

Have a question or interested in learning more about Altido and our work?

We’re always looking to connect with those who share our commitment to advancing new approaches in glioblastoma. Reach out to start a conversation.

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